PC3 (PC-3) human prostate cancer cells cell lines are one of the cell lines used in prostate cancer cells study. These cells serve in looking into the biochemical adjustments in advanced prostatic cancer cells and in assessing their feedback to chemotherapeutic brokers. Additionally, they can be utilized to develop subcutaneous lumps in computer mice in order to explore a model of the tumor atmosphere in the context of the organism.
PC3 cells have higher metastatic possibility as compared to DU145 cells which have a mild metastatic potential and to LNCaP cells which have low metastatic capacity.
PC3 cell lines were set up in 1979 from bone transition of grade IV of prostate cancer in a 62-year-old Caucasian guy. These cells do not reply to androgens, glucocorticoids, or skin or fibroblast growth factors.
PC3 have reduced testosterone-5-alpha reductase and acidic phosphatase activity, do not reveal PSA (prostate-specific antigen), and are PSMA-negative (prostate-specific membrane layer antigen).
Moreover, karyotypic evaluation has shown that PC3 are near-triploid, providing 62 chromosomes. Q-band analysis revealed no Y chromosome. From a morphological point of view, electron microscopy exposed that PC3 show attributes of poorly-differentiated adenocarcinoma. They have functions usual to neoplastic cells of epithelial origins, such as various microvilli, junctional complexes, uncommon centers and nucleoli, irregular mitochondria, annulate lamellae, and lipoidal bodies.
PC3 also may refer to:.
PC3, prostate cancer cell.
Paul Colman Triad, Christian band.
Pasture Capital Convention Center, a convention facility in Springfield, IL, United States.
The Clandestine Colombian Communist Party, an illegal Colombian political celebration.
Abbreviation of Physical Containment Level 3, a study center qualification used in Australia (third highest of 4 degrees, PC1-PC4).